I didn't go into politics because I wanted to win a popularity contest.

Peer pressure and social norms are powerful influences on behaviour, and they are classic excuses.

We will empower patients as well as health professionals. We will disempower the hierarchy and bureaucracy.

I became a Conservative in the late 1980s because I could see that the Conservative party had transformed Britain's economy and our standing in the world compared to Labour in the 1980s.

I have spent too long with too many people who have lost loved ones to healthcare-associated infections not to be determined to act on this. There is no tolerable level of preventable infections. The only acceptable strategy is a zero-tolerance strategy.

I know that nurses are not only the largest healthcare profession but are responsible for the delivery of most healthcare, and are often in the best place to be able to see the whole pathway of care.

If I'm serious about patients and their GPs being able to have more control of their health care, I can't have a top-down system that imposes restrictions on the services they need.

In the first speech I delivered as health secretary, I made one thing perfectly clear: we need a cultural shift in the NHS: from a culture responsive mainly to orders from the top down to one responsive to patients, in which patient safety is put first.

Jamie Oliver, quite rightly, was talking about trying to improve the diet of children in schools and improving school meals, but the net effect was the number of children eating school meals in many of these places didn't go up, it went down.

Not reforming the NHS would have been a much easier decision for me as secretary of state to have taken. We could have just protected the NHS from cuts, put in an extra £12.5bn and left it there. But sooner or later the cracks would have started to show. New treatments would have been held back.

Safe care saves lives and saves money. Adverse events like high levels of infection, blood clots or falls in hospital, emergency readmissions and pressure sores cost the NHS billions of pounds every year. There is a serious human cost, too, with patients ending up injured, or even dead. Most are avoidable with the right care.

Tackling the environment should not be a licence to lecture people, because they have no excuse not to exercise, or eat their fruit and vegetables. Nannying - at least among adults - is likely to be counterproductive. Providing information is empowering; lecturing people is not. So, no excuses, no nannying.

Tell people that biology and the environment cause obesity and they are offered the one thing we have to avoid: an excuse. As it is, people who see more fat people around them may themselves be more likely to gain weight.

The culture is about moving to a place where tobacco and smoking isn't part of normal life: people don't encounter it normally, they don't see it in their big supermarkets, they don't see people smoking in public places, they don't see tobacco vending machines.

The job of the government - and my responsibility - is to help people live healthier lives. The framework is about giving local authorities the ability to focus on the most effective ways to improve the public's health and reduce health inequalities, long-term, from cradle to grave.

We have to treat smoking as a major public health issue. We have to reduce the extent to which young people start smoking, and one of the issues is the extent to which display of cigarettes and brands does draw young people into smoking in the first place.

We know, in Wales or in England - you simply can't trust Labour on the NHS. In England, we are delivering for patients while Labour just use the NHS as a political football. We won't let them; we'll always fight for the NHS.

We must not constantly talk about tackling obesity and warning people about the negative consequences of obesity. Instead we must be positive - positive about the fun and benefits to be had from healthy living, trying to get rid of people's excuses for being obese by tackling the issue in a positive way.

You all know my commitment to the National Health Service. While I am Secretary of State, the NHS will never be fragmented, privatised or undermined. I am personally committed to an NHS which gives equal access, and excellent care.