Francis Crick's Profile
Brief about Francis Crick: By info that we know Francis Crick was born at 1916-06-08. And also Francis Crick is English Scientist.
Some Francis Crick's quotes. Goto "Francis Crick's quotation" section for more.We've discovered the secret of life.
Tags: Discovered, Life, SecretIf poly A is added to poly U, to form a double or triple helix, the combination is inactive.
Tags: Added, Double, TripleA comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.
Tags: Between, Changes, FairA final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
Tags: Here, Ideas, StudiesAttempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
Tags: Order, Study, UntilDo codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap.
Tags: Read, Seems, WordsFor simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.
Tags: Few, Point, SimplicityHow is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
Tags: Divided, Group, ShowIf the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
Tags: Bad, Both, GoodIf, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
Tags: Place, Start, ThreeIt has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
Tags: Direct, Evidence, IndeedIt is one of the more striking generalizations of biochemistry - which surprisingly is hardly ever mentioned in the biochemical textbooks - that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
Tags: Four, Nature, StrikingIt now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.
Tags: Acid, Determined, SeemsIt now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
Tags: Another, May, SeemsIt seems likely that most if not all the genetic information in any organism is carried by nucleic acid - usually by DNA, although certain small viruses use RNA as their genetic material.
Tags: Material, Seems, SmallIt would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
Tags: Less, Nature, RatherMoreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.
Tags: Genuine, Needed, SystemThe balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
Tags: May, Rather, StudyRelated topics
- Catherine Crier
- Robert Crippen
- Stafford Cripps
- Quentin Crisp
- Francesco Crispi
- Darren Criss
- Peter Criss
- Charlie Crist
- Jim Croce
- Steve Crocker